
Received: JanuAccepted: JPublished: July 14, 2015Ĭopyright: © 2015 Han et al. PLoS ONE 10(7):Įditor: Friedemann Paul, Charité University Medicine Berlin, GERMANY (2015) Obstruction of Venous Drainage Linked to Transient Global Amnesia. TGA patients have a higher prevalence of compression/stenosis of the bilateral IJV and the left BCV and TS hypoplasia, which is new evidence that supports the role of extracranial veins in TGA pathogenesis.Ĭitation: Han K, Chao A-C, Chang F-C, Chung C-P, Hsu H-Y, Sheng W-Y, et al. 0.41☐.19, P = 0.0290), which was compatible with downstream venous stenosis/obstruction. The diameter of the left TS in MRV, but not in T1 contrast imaging, was significantly smaller in TGA patients than in controls (0.31☐.21 vs. The prevalence of at least one site of venous compression/stenosis in IJV or BCV was significantly higher in patients than in controls (91.1% vs. Compared to the controls, TGA patients had significantly higher rates of moderate and severe compression/stenosis at the bilateral upper-IJV segment (left: 37.8% vs. The IJV was divided into the upper- and middle-IJV segments.

A magnetic resonance (MR) imaging protocol was used in 45 TGA patients and 45 age- and sex-matched controls to assess the morphologies of IJV, brachiocephalic vein (BCV) and asymmetry of transverse sinus (TS). We hypothesize that obstruction of IJV venous drainage is a contributing factor in TGA pathogenesis. Evidence suggests that the transmission of the intrathoracic/intraabdominal pressure during a Valsalva maneuver (VM) is mainly through the vertebral venous system, and patency of internal jugular vein (IJV) is essential for venous drainage and pressure releasing. Abnormal extracranial venous drainage modality has been considered an etiology of transient global amnesia (TGA).
